In 1678, Antonie van Leeuwenhoek identifies crystalline structures while studying seminal fluid, leading to spermidine’s name, derived from "sperm." Leeuwenhoek is renowned for his early work with microscopes and has been coined the father of microbiology.

By the 1990s, spermidine is recognized as a polyamine, a derivative of an amino acid, vital for life, playing roles in stabilizing DNA, facilitating RNA synthesis, protein translation, and fostering cell growth and development.

Research in the early 2000’s showcases the myriad health benefits of spermidine-rich foods, emphasizing its capacity to induce autophagy, its healthy aging properties, and its impacts on cellular protection in cardio, neural, immune, liver, and other critical organ system functions.

In 2010, the co-founder of Longevity Labs, Frank Madeo, describes the role of spermidine in reducing cellular senescence through autophagy. The role of autophagy in cellular health and function gains worldwide recognition in 2016 when Yoshinori Ohsumi is awarded a Nobel Prize for his groundbreaking discoveries on the genetic mechanisms of autophagy.

In 2018, a pivotal study reveals that high dietary intake of spermidine reduces all-cause mortality by an impressive 5.7 years through autophagy, mirroring the effects of fasting. This discovery leads to the foundation of Longevity Labs, creators of the first spermidine-rich dietary supplement, spermidineLIFE™, allowing for approved human studies of the effects of spermidine supplementation.

Today, spermidine is regarded as one of the most promising natural healthy aging molecules. Studies further describing the age-protective effects of spermidine supplementation continue to be published from research institutions across the world, expanding the areas of clinical application.