Getting Started With spermidineLIFE®

As with many of our new customers, you probably have a lot of questions! How do I take it? When do I take it? How do I store it? What should I feel? We're here to help. Below are resources we've gathered to help answer your questions and help you get started with spermidineLIFE®.

spermidineLIFE® Best Practices

As a general recommendation, we suggest taking two (2) capsules at the same time every day with a sufficient amount of liquid to wash down the capsule, as with many naturally derived dietary supplements we also recommend that you take spermidineLife with a meal to facilitate proper digestion. Taking the capsules at the same time each day ensures consistent supplementation.
Although we have found the best results from those who take spermidineLife in the morning, we encourage you to find the best time of day that works for you and your schedule.

How Long Should I Take spermidineLIFE®?

The recommended dosage of spermidineLIFE is one milligram spermidine per day (2 capsules of spermidineLIFE®), this is considered a “maintenance” dose of spermidine, which is safe to take daily for as long as you wish. Increased levels of spermidine and polyamines will begin to take effect on a cellular level from day one. We recommend beginning with a 60-day cycle to allow your cells to adjust to higher spermidine levels and the enhanced autophagy benefits.

If you choose to routinely “cycle” spermidineLIFE (i.e., not taking consistently), we recommend cycling with a minimum of 60-day cycles (meaning 60-days on, following with 30-days off, and so forth). Our cells do not adjust as fast as one might imagine, to consistent changes in diet. Just as you may not see or feel the benefits of a change in diet over a 24-hour period, you will not see or feel the benefits of a dietary supplement over one 24-hour period.

When Will I Feel the Effects of spermidineLIFE®?

Each and every one of our body’s intestinal microbiota and physiology are different. We have different diets, ages, health profiles, cellular stress levels, and health habits. Autophagy leads to a normalization of cell function through breaking down unused cellular matter, resulting in increased cellular efficiency and function. This micro-change in our bodies can manifest in many different ways. For some, particularly those with health profiles that lead to consistent autophagy anyway, there may be little to no noticeable physiological changes within a 30-60 day cycle. This does not mean spermidine is doing nothing, it is simply further enhancing your healthy cellular lifestyle, which may not necessarily be a “change” for the healthiest among us. We know that spermidine levels decrease significantly with age, so older populations tend to “feel” spermidine supplementation faster and more acutely than younger populations. That being said, spermidine supplementation at a younger age can increase cellular health into older age, a “key” to cellular longevity.


From our research and anecdotal reports, users may experience any one of a number of the following noticeable physiological changes through spermidine supplementation:

  • Increased hair/nail growth
  • Increased energy and metabolism
  • Decreased inflammatory markers, often associated with point-specific injuries or cellular damage
  • Increased mental clarity
  •  Increased deep sleep (as a proportion of overall sleep)
  • Increased sexual health markers (yes, our cells play a role in this too!)
  • Increased immune-efficiency

This list is ongoing, both in research and in anecdotal reports. If you find something specific, drop us a line and let us know your own experience with spermidineLIFE!

How do I Store My spermidineLIFE®?

SpermidineLIFE will remain shelf-stable for 16 months or longer, when stored in its original container in a cool, dry place. Furthermore, you can store spermidineLife in the refrigerator to maintain the most stable product.

Prolonged exposure to direct sunlight, high humidity, or high temperatures (above 77 degrees Fahrenheit) can lead to degradation in the appearance and color of the extract, however, current studies show no loss of effectiveness in the product after exposure.

Have More Questions? Check Out Our FAQ

Will Taking spermidineLIFE Break My Fast?

Officially, we must advise that you seek advice from a healthcare practitioner on this topic. Additionally, as you may find in your own research on the topic, the science is still not clearly settled on what exact type and amount of calories kicks our bodies out of autophagy and ketosis.


That being said, it is generally recognized that the trigger for “ending” a fast is when the body creates an insulin response. While most of the contents of spermidineLIFE distinctly fall into the “healthy fats” category, there is a tiny amount of carbohydrates in spermidineLIFE, approximately five milligrams per serving. From our early research, this volume is generally insufficient to trigger an insulin response; thus, on a scientific level, spermidineLIFE should not “break” a fast.

If you want to “hedge your bets” during your fast, take spermidineLIFE (and your other supplements!) before you fast and/or after. During an extended fast, it is your personal preference if you choose to abstain from supplementation.

Below are our general guidelines for spermidineLIFE® consumption while fasting:

Intermittent Fasting: If you are intermittent fasting, we recommend taking spermidineLIFE® with your last meal of the day to enhance your body’s move into ketosis and autophagy.

Extended (24+ hour) Wet Fast: Take spermidineLIFE® with water at the same time of day as you normally take it during an extended wet fast to enhance autophagy during your fast.

Extended Dry Fast: As liquid intake with spermidineLIFE® appears to aid in digestion, we do not recommend taking spermidineLIFE® during an extended dry fast. Resume taking spermidineLIFE® after your dry fast to ensure lasting benefits of autophagy.

Can I Open the spermidineLIFE Capsules and Take with Food or Liquid? 

Absolutely! spermidineLIFE capsules can be opened, and the pure extract can be mixed with ROOM TEMPERATURE or COLD foods and beverages. Polyamines are quite delicate, and heat can damage polyamine properties (research is ongoing on how this impacts polyamine-containing foods during food preparation), therefore we do not recommend adding the spermidineLIFE extract to hot beverages such as coffee or tea or hot foods like soups.


If you are wondering about taste, the taste is quite tolerable, a little sweet and a little salty tasting. The taste of the extract has said to be similar to a powdered milk flavor (but for the record- there is no lactose or dairy in spermidineLIFE).

Is spermidineLIFE® Vegetarian? 

Yes! spermidineLIFE® capsules are vegetarian.

Are spermidineLIFE® Capsules Vegan?

Yes! spermidineLIFE® capsules are vegan.

Does spermidineLIFE® Contain Gluten?

Yes, spermidineLIFE® contains wheat and gluten. spermidineLIFE® contains around 1,700 mg of gluten per 1kg of spermidineLIFE extract, or about 1.36mg of gluten per recommended daily dose. For context, a 1oz slice of white bread can contain over 3,500mg of gluten. We do not recommend spermidineLIFE® for those with gluten intolerance or coeliac disease.