In September 2023, the Economist produced a review of the current methods employed and researched to slow aging in humans. The series of articles spanned a variety of background and current topics in research surrounding longevity. Autophagy was a centerpiece of the article. On page 11, this discussion turns to autophagy and spermidine:
"Genetic inhibition of autophagy accelerates ageing in laboratory animals. Its stimulation increases healthspan and lifespan.
One way to stimulate [autophagy] is with a molecule called spermidine. This extends the lifespan of mice by up to 25%. Metformin, the type-2 diabetes drug being looked at for broader anti-ageing activities, also boosts autophagy. Rapamycin may do so, too. Biochemistry is a tangled web. It is perhaps not surprising that pathways which regulate what cells do according to the energy available might take an interest in the disposal of surplus proteins."
Spermidine remains in a class of its own as a natural autophagy stimulant without the need for an off-label drug use and prescription. While The Economist article highlights the lifespan and healthspan improvements of spermidine-induced autophagy, there is a deeper impact in the immediacy of increasing dietary spermidine intake. At the cellular level, upregulated autophagy through spermidine has proven in research to be age protective through autophagy and stem cell growth. At the organism level, this has proven results in humans and model organisms in aging, neuroprotection, cardio protection, immune function and memory, stem cell growth, fertility, sleep, mood/depression, and a variety of other indication areas.
Spermidine remains one of the most promising natural youth-extending molecules and has held the test of time in research across the globe. spermidineLIFE™ and its CelVio™ spermidine-rich wheat germ extract remains the first, and the only, human-tested, naturally extracted, award winning, European Food Safety Approved spermidine supplement available worldwide.
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